Participation of hemoglobins A and F in polymerization of sickle hemoglobin.
نویسندگان
چکیده
منابع مشابه
Participation of hemoglobins A and F in polymerization of sickle hemoglobin.
We have measured the solubility of sickle hemoglobin by ultracentrifugation of concentrated solutions of deoxyhemoglobins S + A and S + F in 0.06 I phosphate, pH 7.0. Cyanmethemoglobin derivatives were deoxygenated, mixed, and reduced with dithionite in such a way as to produce gelled deoxyhemoglobin solutions containing 50% asymmetrical hybrid tetramers (a~3~/3* or CU#+~) and solutions contain...
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Studies on abnormal hemoglobins. III. The interrelationship of type S (sickle cell) hemoglobin and type F (alkali resistant) hemoglobin in sickle cell anemia.
AULING ali(l ilis associates’ dlemonstrat.ed that the erythrocytes of mdiVidlUtils with siCkle (‘eli disease colitaill Varyilig quantities of an electrophoretically abtiormal hemoglobin (which we have called type 5).2 In carriers of the sickle cell trait, the red cells contained from 24 to 45 per cent3 of this pathologic pigment, whereas in patients with sickle cell anemia only the abnormal hem...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1977
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)40407-8